Aprile 23, 2024

Pirene para-N-metilpiridinio 2- e 2,7-sostituito

La fluorescenza risolta nel tempo ha mostrato una forte interazione del monomero di porfirina in nanogruppi (τ  2   ≅ 11 ns con una quantità di circa il 90%) ed è stata osservata una leggera autoaggregazione delle porfirineLa determinazione comparativa dell’ossigeno singoletto (ϕ  Δ CAPTISOL  / TMPyP  = 0,58) ha permesso di valutarne il potenziale fotodinamico. Gli studi di rilascio e fotostabilità sono stati condotti in condizioni fisiologiche, indicando il ruolo di CAPTISOL nel sostenere il rilascio di porfirina per oltre 2 settimane e nel proteggere il PS dalla fotodegradazione. Infine, è stata esaminata l’attività fotomicrobica dei nano-assiemi rispetto alla porfirina libera contro P.aeruginosa gram-negativo, E. coli e S. aureus gram-positivo.

  • I nanosistemi proposti sono stati in grado di foto-uccidere cellule batteriche sia gram-positive che negative, nonché TMPyP a MBC  90   = 6 µM TMPyP e alla dose di luce di 42 J /  cm2. Tuttavia, per quanto riguarda il TMPyP libero meno selettivo nei siti biologici, i nano-assiemi mostrano proprietà di rilascio prolungato e una maggiore fotostabilità, ottimizzando così l’effetto PDT nel sito di azione.
  • Questi risultati potrebbero aprire la strada alla ricerca traslazionale in vivo sui nano (foto) farmaci e sulla nanoterapia basata su preparati CD e PS più economici.
  • Sono stati sintetizzati due composti N-metilpiridinio e analoghi sali N-protonati di composti 4-piridil-pirenici sostituiti con 2 e 2,7 e sono state studiate le loro strutture cristalline, le proprietà fotofisiche sia in soluzione che allo stato solido, le proprietà elettrochimiche e spettroelettrochimiche.
  • Dopo la metilazione o la protonazione, i massimi di emissione sono significativamente spostati in batocromo rispetto ai composti neutri, sebbene i massimi di assorbimento rimangano quasi invariati. Di conseguenza, i composti cationici mostrano spostamenti di Stokes apparenti molto grandi fino a 7200 cm -1.
  • I composti N-metilpiridinio mostrano una singola riduzione a circa -1,5 V vs. Fc / Fc + in MeCN. Mentre il processo di riduzione era reversibile per il composto 2,7-disostituito, era irreversibile per il composto monosostituito. I risultati sperimentali sono integrati da calcoli DFT e TD-DFT. Inoltre, i composti N-metilpiridinio mostrano forti interazioni con il timo di vitello (ct) -DNA, presumibilmente per intercalazione, aprendo la strada a ulteriori applicazioni di questi composti multifunzionali come potenziali agenti bioattivi del DNA.

 

Nella ricerca di nuovi leganti del solco del DNA, sono state sintetizzate una serie di antraceni 9,10-metilpiridinici sostituiti e sono state studiate le loro interazioni con il DNA mediante assorbimento UV/vis, spettroscopia CD e fluorescenza.

  • La modalità di legame dei solchi più piccoli è confermata dagli studi sulla fusione del DNA, dai forti effetti del CD, dalla relazione tra l’affinità di legame alla forza ionica e dalla differenziazione tra le coppie di basi AT e GC.
  • Non vi è alcun legame con le sequenze GC. Sono state determinate le costanti di legame del DNA del timo di vitello (ct-DNA) e del poli (dA: dT) comprese tra 1 × 104 e  3   ×  105   M  -1   .
  • La forza di legame diminuisce con la dimensione dei sostituenti attaccati al sito dell’antracene. Il cambiamento nel modello di sostituzione dei gruppi carichi mostra che i gruppi metilici nella meta posizione si legano leggermente più forte dei gruppi parametilici.
  • Contrariamente a questi gruppi, non è stata osservata alcuna interazione di legame nella posizione orto. Il legame più forte si ottiene con l’espansione dell’eterociclo periferico dalla piridina alla chinolina. La modellazione molecolare rivela il ruolo chiave del pattern di sostituzione: le antracine para e metapiridiniche si allineano lungo solchi più piccoli. La derivata orto, invece, non prende l’allineamento del solco.
  • Le strutture di diffrazione dei raggi X monocristalline del 5-ammino-2-metilpiridinio idrogeno fumarato sono state risolte a 150 e 300 K (CCDC 1952142 e 1952143). L’anello base-acido-base-acido è formato da legami idrogeno piridinio-carbossilato e ammina-carbossilato, che tengono insieme le catene di ioni idrogeno fumarato legati da legami idrogeno.
  • Gli spostamenti chimici   1H e   13C   , così come   gli spostamenti 14   N, che dipendono inoltre dall’interazione del quadrupolo, sono determinati dalla risonanza magnetica nucleare (NMR) sperimentale allo stato solido con rotazione dell’angolo magico (MAS) e onda di proiezione estesa (GIPAW) tenendo conto la marcatura. calcolo.
  •   Sono mostrati gli spettri omonucleari MAS  bidimensionali 1H-1H a due quanti (  DQ  )  e gli spettri eteronucleari 1H- 13C   e   14N  – 1H   . Tra i calcoli GIPAW si osservano solo lievi differenze fino a 0,1 ppm e 0,6 ppm per   1H   e   13C   , a partire dalle due strutture risolte a 150 e 300K (dopo l’ottimizzazione della geometria delle posizioni degli atomi ma non della cella unitaria parametri). Un confronto dei  cambiamenti chimici 1H calcolati da GIPAW   per molecole isolate e strutture cristalline complete indica la forza del legame idrogeno.

I trasportatori di cationi organici umani 1 (hOCT1) e 3 (hOCT3) sono altamente espressi negli epatociti e svolgono un ruolo importante nell’assorbimento, distribuzione ed eliminazione dei cationi.

  • Ricerche precedenti hanno mostrato che l’abbassamento  dei livelli di mRNA di hOCT1 e hOCT3 era associato alla prognosi e alla gravità del carcinoma epatocellulare (HepG2). Non è stato studiato se questi trasportatori espressi nelle cellule HepG2 servano per la consegna di farmaci cationici. A parte il trasporto radioattivo, le possibilità di valutare l’hoCT negli epatociti sono limitate.
  • Questo studio ha chiarito l’importante ruolo di hOCT in HepG2 confrontando il fluorescente cationico 4- (4- (dimetilammino) stiril) -N-metilpiridinio (ASP  +   ) con il tradizionale [  3H   ] -1-metil-4-fenilpiridina (MPP). +   ). I risultati hanno mostrato che ASP  +   è stato trasportato vantaggiosamente in HepG2 rispetto a [  3H   ] -MPP  +   con alta affinità e un’elevata velocità di trasporto massima.
  •  Il trasporto selettivo di ASP  +   tramite hOCT è stato influenzato dal pH extracellulare, dalla temperatura e dalla depolarizzazione della membrana, coerentemente con l’espressione di hOCT1 e hOCT3.
  • Inoltre, il trasporto di farmaci cationici, metformina e paclitaxel nelle cellule HepG2 è stato compromesso dagli inibitori dell’OCT, suggerendo che hOCT1 e hOCT3 espressi nelle cellule HepG2 hanno avuto un effetto significativo sull’azione dei farmaci cationici. Un modello in vitro basato su ASP + fluorescente    potrebbe anche fornire uno strumento analitico rapido ed efficiente per un ulteriore screening degli effetti dei farmaci cationici e delle interazioni con hOCT, in particolare hOCT1 e hOCT3 nel carcinoma epatocellulare.

 

È ora imperativo sviluppare nanoformulazioni nuove e meno costose per la somministrazione controllata in situ e sicura di fotosensibilizzanti (PS) contro agenti patogeni opportunisti nelle aree di infezione del corpo. La terapia fotodinamica antimicrobica (aPDT) è un approccio promettente per il  trattamento delle infezioni batteriche resistenti agli antibiotici. In questo articolo, proponiamo di progettare e caratterizzare un nuovo agente nanofototerapico a base della ciclodestrina commerciale CAPTISOL (solfobutiletere-beta-ciclodestrina, SBE-βCD) e 5, 10, 15, 20-tetrakis (1-metilpiridinio-4-il ) tetrakis (p-toluensolfonato). ) porfine (TMPyP) per la produzione di efficienti sistemi biocompatibili per aPDT.

 

3-(3,5-Dioxo-3H-1,2,4-triazol-4(5H)-yl)-1-methylpyridin-1-ium Iodide

C124550 Toronto Research Chemicals 250mg 4500 EUR

1-(1-Adamantyl)-4-methylpyridinium Bromide

A433080 Toronto Research Chemicals 1g 800 EUR

3,3'-((1E,1'E)-(9-(2-(2-(2-(2-(1-methylpiperidin-1-ium-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-9H-carbazole-2,7-diyl)bis(ethene-2,1-diyl))bis(1-methylpyridin-1-ium) iodide

M330465 Toronto Research Chemicals 25mg 19000 EUR

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-yl)methylpyridinium Bromide

B276150 Toronto Research Chemicals 500mg 1800 EUR

1-(1H-Benzimidazol-2-yl)-4-(3methoxypropoxy)-3-methylpyridinium-2-carboxylate

B202983 Toronto Research Chemicals 25mg 7600 EUR

4-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium Chloride

B486100 Toronto Research Chemicals 0.5mg 1455 EUR

1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride Hydrochloride

A618530 Toronto Research Chemicals 10g 155 EUR

1-Methyl-pyridinium Chloride

M328060 Toronto Research Chemicals 1g 121 EUR

4,4'-[9H-Carbazole-3,6-diyldi-(1E)-2,1-ethenediyl]bis[1-methyl-pyridinium Diiodide (>90%)

C176070 Toronto Research Chemicals 500mg 181 EUR

4,4'-[9H-Carbazole-3,6-diyldi-(1E)-2,1-ethenediyl]bis[1-methyl-pyridinium Diiodide-d6

C176072 Toronto Research Chemicals 25mg 1200 EUR

1-Benzyl-3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium Bromide

B279930 Toronto Research Chemicals 100mg 201 EUR

1-Benzyl-3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium Bromide

B288990 Toronto Research Chemicals 25mg 800 EUR

1-Benzyl-3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium-d2 Bromide

B279933 Toronto Research Chemicals 1mg 1246 EUR

1-Benzyl-3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium-d3 Bromide

B288992 Toronto Research Chemicals 25mg 1200 EUR

(R)-2-((R)-Carboxy((Z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetamido)methyl)-5-((4-(1-methylpyridin-1-ium-4-yl)thiazol-2-yl)thio)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate

C183683 Toronto Research Chemicals 25mg 4500 EUR

Osimertinib N'-Methylpyrrolidone Iodide

O702280 Toronto Research Chemicals 25mg 9200 EUR

2‐FLUORO‐4‐IODO‐5‐METHYLPYRIDINE

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4-Methyl-N-(5-methyl-2-pyridinyl)benzamide

M320370 Toronto Research Chemicals 100mg 132 EUR

4-Methylpyridine-2,3-diamine

20-abx183629 Abbexa
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4-Methylpyridine-2,6-diamine

M329075 Toronto Research Chemicals 5g 800 EUR

4-Methyl-pyridine-2,5-diamine

M341015 Toronto Research Chemicals 1g 800 EUR

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-

T9837-10mg TargetMol Chemicals 10mg Ask for price

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-

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N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-

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N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-

T9837-50mg TargetMol Chemicals 50mg Ask for price

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-

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1-(6-Methylpyridin-3-yl)-2-((4-(2-(6-methylpyridin-3-yl)-2-oxoethyl)phenyl)sulfonyl)ethanone

M314690 Toronto Research Chemicals 500mg 500 EUR

5-Methylpyridin-3-ol

M327055 Toronto Research Chemicals 100mg 81 EUR

3-Methylpyridin-2-ol

M337948 Toronto Research Chemicals 100mg 75 EUR

4-Methylpyridine

abx185236-100g Abbexa 100 g 260.4 EUR

4-Methylpyridine

M320745 Toronto Research Chemicals 50g 150 EUR

(5-Methylpyridin-3-Yl)Methanol

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(3-Methylpyridin-2-yl)methanol

M337935 Toronto Research Chemicals 100mg 81 EUR

4-​Ethyl-​2-​methylpyridine

E938663 Toronto Research Chemicals 500mg 1200 EUR

2‐AMINO‐3‐METHYLPYRIDINE

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2‐AMINO‐5‐METHYLPYRIDINE

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2-​Amino-​6-​methylpyridine

A613985 Toronto Research Chemicals 25g 52 EUR

2–Amino–6–methylpyridine

RM2638-100G EWC Diagnostics 1 unit 29.4 EUR

6-Methyl-3-pyridinol

M328295 Toronto Research Chemicals 10g 115 EUR

N-(3-Methyl-2-pyridinyl)-2-thiophenecarboxamide

M329125 Toronto Research Chemicals 250mg 800 EUR

Methyl 4-[(6-Methylpyridin-2-yl)oxy]benzoate

M255420 Toronto Research Chemicals 500mg 800 EUR

4-(2-Hydroxy-1-(4-hydroxy-3-(hydroxymethyl)-5-methylpyridin-2-yl)ethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol

H667575 Toronto Research Chemicals 50mg 15000 EUR

(2-methylpyridin-4-yl)methanamine

abx184845-1g Abbexa 1 g 1395.6 EUR

(6-Methylpyridin-2-yl)methanamine

20-abx184861 Abbexa
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(4R)-4-(3-Iodophenyl)-1-[(3-methyl-4-pyridinyl)methyl]-2-pyrrolidinone

I708690 Toronto Research Chemicals 25mg 9200 EUR

(4S)-4-(3-Iodophenyl)-1-[(3-methyl-4-pyridinyl)methyl]-2-pyrrolidinone

I708695 Toronto Research Chemicals 25mg 9200 EUR

N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole

M265170 Toronto Research Chemicals 250mg 201 EUR

1-(6-Methylpyridin-2-yl)piperazine

M329290 Toronto Research Chemicals 5g 800 EUR

1-(4-Methylpyridin-2-yl)piperazine

M329315 Toronto Research Chemicals 2.5g 800 EUR

Methyl 4-Methylpyridin-3-ylcarbamate

M223298 Toronto Research Chemicals 1g 800 EUR

4-(((5-Hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methoxy)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol Dihydrochloride

P991220 Toronto Research Chemicals 50mg 7600 EUR

2-Methylpyridineborane

20-abx185080 Abbexa
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6-Methylpyridine-3-amine

M327020 Toronto Research Chemicals 1g 569 EUR

(5-((5-Hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methoxy)-6-methylpyridine-3,4-diyl) Dimethanol Hydrochloride

P991100 Toronto Research Chemicals 50mg 9200 EUR

4-Methyl-2-pyridinethiol

M328155 Toronto Research Chemicals 500mg 1292 EUR

5-Methylpyridin-2-one Pirfenidone

M493285 Toronto Research Chemicals 100mg 735 EUR

(6-Methyl-3-pyridinyl)methanol

TNU0893-10mg TargetMol Chemicals 10mg Ask for price

(6-Methyl-3-pyridinyl)methanol

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(6-Methyl-3-pyridinyl)methanol

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(6-Methyl-3-pyridinyl)methanol

TNU0893-50mg TargetMol Chemicals 50mg Ask for price

(6-Methyl-3-pyridinyl)methanol

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6-Methylpyridine-2-ethanol

20-abx182315 Abbexa
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Borane-​2-​methylpyridine Complex

B675375 Toronto Research Chemicals 10g 173 EUR

6-Methyl-3-pyridineethanol

M326800 Toronto Research Chemicals 1g 800 EUR

2-(Bromomethyl)-4-methylpyridine

B688545 Toronto Research Chemicals 2.5g 1800 EUR

1-(5-Methylpyridin-2-yl)-1H-benzo[d][1,2,3]triazole-d3

M320772 Toronto Research Chemicals 10mg 845 EUR

2-(Methoxymethyl)-6-methylpyridine

M336793 Toronto Research Chemicals 2.5g 115 EUR

N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide

M265175 Toronto Research Chemicals 500mg 190 EUR

N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfone

M265180 Toronto Research Chemicals 10mg 603 EUR

4-Methylpyridine-3-Boronic Acid

20-abx180559 Abbexa
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2-Methylpyridine-4-boronic acid

20-abx185078 Abbexa
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5-Methylpyridine-3-Boronic Acid

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2-Chloro-4-((6-methylpyridin-2-yl)oxy)benzoic Acid

C416145 Toronto Research Chemicals 500mg 1200 EUR

2-Chloro-4-((4-methylpyridin-2-yl)oxy)benzoic Acid

C416155 Toronto Research Chemicals 500mg 1200 EUR

1-(5-Methyl-2-pyridinyl)piperazine

M329280 Toronto Research Chemicals 5g 800 EUR

1-(3-Methyl-2-pyridinyl)piperazine

M329285 Toronto Research Chemicals 100mg 138 EUR

3-[(4-Methyl-2-pyridinyl)oxy]benzoic Acid

M416145 Toronto Research Chemicals 500mg 1200 EUR

3-(2-Methyl-1,3-dioxolan-2-yl)-6-methylpyridine

M303640 Toronto Research Chemicals 100mg 110 EUR

Methyl 3-Methyl-4-Pyridinecarboxylate

20-abx182537 Abbexa
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Methyl 3-Methylpyridine-2-Carboxylate

abx186500-25g Abbexa 25 g 292.8 EUR

3-(6-Methyl-3-pyridinyl)propanoic Acid

M340000 Toronto Research Chemicals 100mg 150 EUR

(4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methanol

M266065 Toronto Research Chemicals 100mg 207 EUR

1-(5-Methyl-2-pyridinyl)piperazine-d8

M329282 Toronto Research Chemicals 10mg 1200 EUR

2-Methylpyridine-4-carbaldehyde

20-abx185079 Abbexa
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2-Methylpyridine-4-carboxylic acid

20-abx183245 Abbexa
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5-Methylpyridine-2-carboxylic acid

20-abx183753 Abbexa
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6-Methyl-3-pyridineacetonitrile

M337915 Toronto Research Chemicals 500mg 1800 EUR

3-Hydroxy-1-(4-hydroxyphenyl)-5-methylpyridin-2-(1H)-one

H943145 Toronto Research Chemicals 250mg 4500 EUR

2-(2-(4-Bromophenoxy)ethyl)-3-methylpyridine

B687220 Toronto Research Chemicals 250mg 3000 EUR

4-Amino-1,3-dihydro-1-[(6-methyl-3-pyridinyl)methyl]-6-   [(tetr

TNU0892-10mg TargetMol Chemicals 10mg Ask for price

4-Amino-1,3-dihydro-1-[(6-methyl-3-pyridinyl)methyl]-6-   [(tetr

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4-Amino-1,3-dihydro-1-[(6-methyl-3-pyridinyl)methyl]-6-   [(tetr

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4-Amino-1,3-dihydro-1-[(6-methyl-3-pyridinyl)methyl]-6-   [(tetr

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4-Amino-1,3-dihydro-1-[(6-methyl-3-pyridinyl)methyl]-6-   [(tetr

TNU0892-5mg TargetMol Chemicals 5mg Ask for price

6-Methylpyridine-2-carboxylic acid methyl ester

abx183802-100g Abbexa 100 g 861.6 EUR

6-Methylpyridine-3-carboxaldehyde

20-abx182316 Abbexa
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5-​Ethyl-​2-​methylpyridine(5-Ethyl-2-picoline)

E925530 Toronto Research Chemicals 100g 68 EUR

3-Methyl-4-pyridinecarboxylicacid

20-abx180447 Abbexa
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6-Methyl-2-pyridinecarboxaldehyde

M326685 Toronto Research Chemicals 100g 173 EUR

3-Methyl-4-pyridinecarbonyl Chloride

M327045 Toronto Research Chemicals 2.5g 1200 EUR

(2-Methylpyridin-4-yl)methanamine dihydrochloride

20-abx184846 Abbexa
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4-(Aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol

A470870 Toronto Research Chemicals 10mg 59 EUR

1-(2-Methylpyridin-4-yl)ethan-1-amine Hydrochloride

M406490 Toronto Research Chemicals 500mg 1200 EUR

DiA [4-(4-(Dihexadecylamino)styryl)-N-methylpyridinium iodide]

22030-25mg AAT Bioquest 25 mg 86 EUR

3-Methylpyridine-2-carboxylicacid,HCl

20-abx186278 Abbexa
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2-(4-Methylsulfonyl)phenyl-1-(6-methylpyridin-3-yl)ethanone Oxime

M258895 Toronto Research Chemicals 100mg 178 EUR

6-Methyl-2-pyridinecarboximidamide

M337986 Toronto Research Chemicals 1g 1200 EUR

3-((2-(Acetoxymethyl)-3-methylpyridin-4-yl)oxy)propyl Acetate

A167225 Toronto Research Chemicals 5g 1200 EUR

4-Chloro-2-(hydroxymethyl)-3-methylpyridine

C366625 Toronto Research Chemicals 100mg 150 EUR

4-Methyl-1-(3-methyl-2-pyridinyl)-2-phenylpiperazine

M320720 Toronto Research Chemicals 100mg 1777 EUR

8-Methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

T310048 Toronto Research Chemicals 100mg 7600 EUR

6-Methyl-2-pyridinecarboxaldehyde-d3

M326687 Toronto Research Chemicals 2.5mg 1920 EUR

1,4-bis(6-Methylpyridin-3-yl)-2,3-bis(4-(methylsulfonyl)phenyl)butane-1,4-dione

M305805 Toronto Research Chemicals 50mg 4500 EUR

2-(4-methylsulfonyl)phenyl-1-(6-methylpyridin-3-yl)ethanone Oxime-d3

M258897 Toronto Research Chemicals 25mg 3000 EUR

2-(4-Methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethanone

M225915 Toronto Research Chemicals 1g 261 EUR

1-(6-Methyl-3-pyridinyl)-2-[4-(methylsulfinyl)phenyl]ethanone

M314585 Toronto Research Chemicals 250mg 3000 EUR

Etoricoxib 2-Methylpyridine (Methylsulfonyl)benzene -d6

E934174 Toronto Research Chemicals 75mg 19000 EUR

Etoricoxib 2-Methylpyridine (Methylsulfonyl)benzene

E934175 Toronto Research Chemicals 100mg 1800 EUR

(R)-4-(3-Bromo-5-fluorophenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one

B392015 Toronto Research Chemicals 25mg 9200 EUR

(S)-4-(3-Bromo-5-fluorophenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one

B392020 Toronto Research Chemicals 25mg 9200 EUR

8-(Methyl-d3)-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-6,7,9-d3

M956733 Toronto Research Chemicals 50mg 17000 EUR

3-Hydroxy-4,5-Bis(Hydroxymethyl)-2-Methylpyridine

20-abx188387 Abbexa
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1-Methyl-2-pyridin-2-yl-ethylamine Dihydrochloride

M337978 Toronto Research Chemicals 1g 1200 EUR

(4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methanol Hydrochloride

M266015 Toronto Research Chemicals 500mg 190 EUR

4-[2-(Methyl-2-pyridinylamino)ethoxy]benzaldehyde

M325330 Toronto Research Chemicals 500mg 800 EUR

2-(2 2-Dicarbethoxyvinylamino)-6-methylpyridine

D12730 Pfaltz & Bauer 10G 320.13 EUR

1-(6-Methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]-ethanone Oxime

M320090 Toronto Research Chemicals 100mg 1800 EUR

4,4'-(Oxybis(methylene))bis(5-(hydroxymethyl)-2-methylpyridin-3-ol) Hydrochloride

P991230 Toronto Research Chemicals 100mg 4500 EUR

4-(3-Hydroxypropoxy)-3-methyl-2-pyridinemethanol

H627300 Toronto Research Chemicals 2.5g 1800 EUR

2-Methyl-8-(methyl-d3)-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2-oxide-6,7,9-d3

M200782 Toronto Research Chemicals 50mg 17000 EUR

(S)-1-(6-((1-(4-Iodophenyl)-4-(methylamino)-4-oxobutan-2-yl)carbamoyl)-5-methylpyridin-3-yl)-N-(6-methyl-3-nitropyridin-2-yl)-1H-indazole-4-carboxamide

I354830 Toronto Research Chemicals 50mg 9500 EUR

1-(6-Methyl-2-pyridinyl)-1H-imidazole-4-carboxylic Acid

M641573 Toronto Research Chemicals 100mg 207 EUR

3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

D461680 Toronto Research Chemicals 100mg 12800 EUR

5-[2-(tert-Butyldimethylsilyloxy)ethyl]-2-methyl-pyridine

B692005 Toronto Research Chemicals 1g 1200 EUR

6-Methylpyridine-3-boronic Acid Hydrochloride Hydrate

M327090 Toronto Research Chemicals 10mg 276 EUR

4-[2-(Methyl-2-pyridinylamino)ethoxy]benzenepropanoic Acid Methyl Ester

M328215 Toronto Research Chemicals 100mg 173 EUR

6-(Dimethylcarbamoyl)-2-methylpyridine-3-carboxylic Acid

D477543 Toronto Research Chemicals 100mg 196 EUR

6-Chloro-2-(6-methyl-3-pyridinyl)-3-[4-(methylsulfonyl)phenyl]-1,8-naphthyridine

C381440 Toronto Research Chemicals 100mg 494 EUR

2,8-Dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2-oxide

D476895 Toronto Research Chemicals 100mg 7600 EUR

1-[2-(3-Cyclohexylpropoxy)-2-oxoethyl]-1-methylpyrrolidin-1-ium Iodide

C955620 Toronto Research Chemicals 250mg 500 EUR

(+/-)-4-Chlorophenyl-5-[(3,4-isopropylidine)-2-methylpyridine]methanol-d4

C378552 Toronto Research Chemicals 2.5mg 1608 EUR

Rupatadine (5-Methyl-3-pyridinyl)methyl)pyridinium Chloride Trihydrochloride

M326742 Toronto Research Chemicals 10mg 184 EUR

2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine Hydrochloride

C368775 Toronto Research Chemicals 100mg 121 EUR

2-(Chloromethyl)-4-(3-chloropropoxy)-3-methylpyridine Hydrochloride

C369080 Toronto Research Chemicals 100mg 230 EUR

2-Fluoro-4-[7-(2-methyl-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]-N-[3-(trifluoromethyl)phenyl]-Benzeneacetamide

F409755 Toronto Research Chemicals 50mg 7600 EUR

1,2,3,6-Tetrahydro-Alpha,4-bis(p-methoxyphenyl)-1-methyl-3-pyridinemethanol

T117590 Toronto Research Chemicals 100mg 328 EUR

4-Borono-N-methylpyridinium Iodide

B689438 Toronto Research Chemicals 100mg 161 EUR

3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)benzoic acid

20-abx181849 Abbexa
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  • 100 mg
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(5R,6S)-6-((R)-1-Hydroxyethyl)-3-(6-methylpyridin-3-yl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

H998135 Toronto Research Chemicals 25mg 31000 EUR

(S)-1-(6-((1-Amino-1-oxo-3-(thiazol-4-yl)propan-2-yl)carbamoyl)-5-methylpyridin-3-yl)-N-(6-methyl-3-nitropyridin-2-yl)-1H-indazole-4-carboxamide

A243720 Toronto Research Chemicals 100mg 6110 EUR

DiA iodide

EGY023 EnoGene 10 mg 100 EUR

4-[2-(Methyl-2-pyridinylamino)ethoxy]benzenepropanamide(Rosiglitazone Impurity)

B288665 Toronto Research Chemicals 100mg 184 EUR

Methylprednisolone 21-Iodide

M331203 Toronto Research Chemicals 10mg 913 EUR

1-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate

B701338 Toronto Research Chemicals 100mg 913 EUR

N-(3-Methyl-2-pyridyl)formamide

M617635 Toronto Research Chemicals 2.5g 800 EUR

Methyl iodide 99%

M20830 Pfaltz & Bauer 25G 162.9 EUR

1-Amino-4-methylpyridinium Iodide

A617445 Toronto Research Chemicals 10g 1200 EUR

Methylnaltrexone iodide

T40845-10mg TargetMol Chemicals 10mg Ask for price

Methylnaltrexone iodide

T40845-1g TargetMol Chemicals 1g Ask for price

Methylnaltrexone iodide

T40845-1mg TargetMol Chemicals 1mg Ask for price

Methylnaltrexone iodide

T40845-50mg TargetMol Chemicals 50mg Ask for price

Methylnaltrexone iodide

T40845-5mg TargetMol Chemicals 5mg Ask for price

N-(Methyl-d3)-4-phenylpyridinium Iodide

M326287 Toronto Research Chemicals 100mg 81 EUR

3-Hydroxy-1-methylpyridinium Iodide

H948005 Toronto Research Chemicals 500mg 800 EUR

Methyl Mercuric Iodide

M21910 Pfaltz & Bauer 10G 254.61 EUR

Quinoline methyl iodide

Q00770 Pfaltz & Bauer 1G 167.06 EUR

Quinaldine methyl iodide

Q00190 Pfaltz & Bauer 5G 140.77 EUR

Methyltributylammonium iodide

M29600 Pfaltz & Bauer 250MG 445.75 EUR

Methyltriphenylarsonium Iodide

M29900 Pfaltz & Bauer 25G 298.86 EUR

Amitriptyline Methyl Iodide

D204450 Toronto Research Chemicals 250mg 1200 EUR

6-Methylnicotinamide Iodide

M323230 Toronto Research Chemicals 1g 425 EUR

1-(((6R,7R)-2-((Benzhydryloxy)carbonyl)-7-((E)-benzylideneamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidin-1-ium Iodide-d8

B658787 Toronto Research Chemicals 100mg 3000 EUR

Methyltriphenoxyphosphonium Iodide

M330990 Toronto Research Chemicals 10g 362 EUR

(6R-trans)-1-[[2-[(Diphenylmethoxy)carbonyl]-8-oxo-7-[(phenylmethylene)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidnium Iodide

D107555 Toronto Research Chemicals 250mg 3000 EUR

(S)-1’-Methylnicotinium Iodide

M323280 Toronto Research Chemicals 100mg 448 EUR

3-Methylbenzothiazolium iodide

M12085 Pfaltz & Bauer 25G 467.4 EUR

(S)-1-Methylnicotinium Iodide

M323275 Toronto Research Chemicals 5mg 138 EUR

Methyl)triphenylphosphonium Iodide-13C

M330999 Toronto Research Chemicals 1g 420 EUR

(Methyl)triphenylphosphonium Iodide

M330995 Toronto Research Chemicals 1g 63 EUR

1-Methyl-nicotinamide Iodide

M323235 Toronto Research Chemicals 1g 125 EUR

1-(11-Hydroxyundecyl)-1-methylpiperidin-1-ium Iodide

H399940 Toronto Research Chemicals 250mg 500 EUR

1-Methyl-2-pyridone 99%

M27330 Pfaltz & Bauer 5G 191.81 EUR

1-Methyl-2-pyridone

M156471 Toronto Research Chemicals 100mg 74 EUR

1-Methyl-4-pyridone

M326460 Toronto Research Chemicals 250mg 234 EUR

3-Methylpyridazine

20-abx181980 Abbexa
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  • 10 g
  • 5 g

4-Methylpyridazine 98%

M27200 Pfaltz & Bauer 100MG 247.5 EUR

3-Methylpyridazine

M337968 Toronto Research Chemicals 100mg 69 EUR

1-Methylnicotinamide-d3 Iodide

M323237 Toronto Research Chemicals 100mg 219 EUR

L-Methionine Methylsulfonium Iodide

M225483 Toronto Research Chemicals 250mg 800 EUR

4-Methyl-pyridazine-3,6-diol

20-abx182128 Abbexa
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  • 100 g
  • 25 g
  • 5 g

Sono stati preparati nanosistemi sferici lunghi circa 360 nm basati su complessi supramolecolari CAPTISOL / TMPyP con stechiometria 1: 1 e costante di equilibrio del legame apparente (Kb     1,32 × 105  M   -1  )  con un’efficienza di intrappolamento ≅ 100% mediante semplice agitazione in un mezzo acquoso e liofilizzazione. Questi sistemi sono stati caratterizzati da tecniche complementari di spettroscopia e microscopia.

 

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